ONPATTRO^® (patisiran) may transform the future for you and your family

A prescription medicine for adults that treats the polyneuropathy caused by an illness called hATTR amyloidosis

Improvement in nerve function in the majority of patients
Improvement in quality of life in the majority of patients
Personalized support throughout the treatment process

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hATTR amyloidosis=hereditary transthyretin-mediated amyloidosis

What are the most important things I should know about ONPATTRO^® (patisiran)?

ONPATTRO can cause:

Infusion-related reactions

ONPATTRO is given as a drip into a vein (called an "intravenous infusion"). Reactions to this infusion may happen during treatment with ONPATTRO. Before
each infusion you will be given medicines that help to lower the chance of infusion-related reactions.

Tell your doctor or nurse right away if you experience any of the following signs of an infusion-related reaction during treatment:

Reddening of the face or body (flushing), skin warm
Body aches or pain, including pain in the back, neck, or joints
Feeling sick (nausea)
Stomach pain
Feeling short of breath, cough, or other breathing problems
Headache
Chest discomfort or chest pain
Rash
Chills
Dizziness
Feeling tired (fatigue)
Rapid heart rate
Facial swelling

If you have an infusion-related reaction, your doctor or nurse may slow down or stop your infusion, and you may need to take other medicines. When these reactions stop, or get better, your doctor or nurse may decide to start the infusion again.

Low Vitamin A levels

Treatment with ONPATTRO lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking ONPATTRO, talk to your doctor. Your doctor may refer you to an eye specialist.

What are the common side effects of ONPATTRO?

The most common side effects of ONPATTRO are respiratory infections, such as colds, sinus infections, and nasal congestion, and infusion-related reactions. These are not all the possible side effects of ONPATTRO. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

ONPATTRO is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). ONPATTRO is used in adults only.

What are the most important things I should know about ONPATTRO^® (patisiran)?

ONPATTRO can cause:

Infusion-related reactions

ONPATTRO is given as a drip into a vein (called an "intravenous infusion"). Reactions to this infusion may happen during treatment with ONPATTRO. Before each infusion you will be given medicines that help to lower the chance of infusion-related reactions.

Tell your doctor or nurse right away if you experience any of the following signs of an infusion-related reaction during treatment:

Reddening of the face or body (flushing), skin warm
Body aches or pain, including pain in the back, neck, or joints
Feeling sick (nausea)
Stomach pain
Feeling short of breath, cough, or other breathing problems
Headache
Chest discomfort or chest pain
Rash
Chills
Dizziness
Feeling tired (fatigue)
Rapid heart rate
Facial swelling

Low Vitamin A levels

Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking ONPATTRO, talk to your doctor. Your doctor may refer you to an eye specialist.

What are the common side effects of ONPATTRO?

ONPATTRO^® (patisiran) may transform the future for you and your family

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Important Safety Information

What are the most important things I should know about ONPATTRO^® (patisiran)?

Infusion-related reactions

Low Vitamin A levels

What are the common side effects of ONPATTRO?

Indication

What is ONPATTRO?

For additional information about ONPATTRO, please see the full Prescribing Information.

Important Safety Information

What are the most important things I should know about ONPATTRO^® (patisiran)?

Infusion-related reactions

Low Vitamin A levels

What are the common side effects of ONPATTRO?

Indication

What is ONPATTRO?

For additional information about ONPATTRO, please see the full Prescribing Information.

ONPATTRO® (patisiran) may transform the future for you and your family

Support through Alnylam Assist®

Share your story

Important Safety Information

What are the most important things I should know about ONPATTRO® (patisiran)?

Infusion-related reactions

Low Vitamin A levels

What are the common side effects of ONPATTRO?

Indication

What is ONPATTRO?

For additional information about ONPATTRO, please see the full Prescribing Information.

Important Safety Information

What are the most important things I should know about ONPATTRO® (patisiran)?

Infusion-related reactions

Low Vitamin A levels

What are the common side effects of ONPATTRO?

Indication

What is ONPATTRO?

For additional information about ONPATTRO, please see the full Prescribing Information.

ONPATTRO^® (patisiran) may transform the future for you and your family

Support through
Alnylam Assist^®

What are the most important things I should know about ONPATTRO^® (patisiran)?

What are the most important things I should know about ONPATTRO^® (patisiran)?