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What is hereditary ATTR (hATTR) amyloidosis?

Symptoms of hATTR amyloidosis can progress quickly, leading to significant disability

It runs in the family

hATTR amyloidosis is caused by a mutation or change in the TTR gene. Any child of a parent with this mutation will have a 50% chance of inheriting the mutation. However, this does not necessarily mean that the child will develop the condition. It's important to understand your family health history and speak with your doctor about how hATTR amyloidosis runs in the family.

Inheriting hATTR amyloidosis

It affects several parts of
the body

hATTR amyloidosis can affect the nerves, heart, and digestive system, which means individuals may experience a range of symptoms that may not seem related to one another.

It often impacts quality
of life:

  • Decreased mobility
  • Gastrointestinal issues
  • Trouble with self-care
  • Difficulty performing usual activities
  • Pain/discomfort
  • Anxiety
  • Depression

The varying symptoms of
hATTR amyloidosis

This is not a complete list of symptoms that may be experienced with hATTR amyloidosis.

hATTR amyloidosis symptoms. ONPATTRO does not treat all of these symptoms.

Adapted from Conceição I, et al. J Peripher Nerv Syst. 2016;21(1):5-9.

ONPATTRO® (patisiran) does not treat all of these symptoms.


There is treatment that may transform the future for you and your family.