What are the possible side effects of ONPATTRO® (patisiran)?

The most common side effects in patients treated with ONPATTRO were respiratory infections such as colds, sinus infections, and nasal congestion, and infusion-related reactions

The most common infusion-related reactions people experienced were:

  • flushing of skin
  • back pain
  • nausea
  • stomach pain
  • difficulty breathing
  • headache

Infusion-related reactions decreased over time.

The majority of side effects were mild to moderate in severity, although some were considered severe.

What Happens If I Get Pregnant?

Tell your doctor right away if you become pregnant or are thinking of becoming pregnant while you are taking ONPATTRO. There may be some risks associated with pregnancy while taking ONPATTRO that your doctor will review with you.

You are encouraged to enroll in the ONPATTRO pregnancy registry should you become pregnant while taking ONPATTRO by calling 1-877-256-9526 or by contacting AlnylamPregnancyProgram@iqvia.com.