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Safety profile of ONPATTRO® (patisiran)

What are possible side effects?

The most frequently occurring side effects in patients treated with ONPATTRO were respiratory infections,
such as colds, sinus infections, and nasal congestion, and infusion-related reactions. The most common infusion-related reactions were:

  • flushing of skin
  • back pain
  • nausea
  • stomach pain
  • difficulty breathing
  • headache

The majority of side effects were mild to moderate in severity, although some were considered severe. Infusion-related reactions decreased over time.