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ONPATTRO® (patisiran) improved polyneuropathy symptoms related to hATTR amyloidosis

Patients receiving ONPATTRO showed improvement in nerve function compared to those who received placebo

Significant improvements in nerve function as measured by:

  • Strength in hands and feet, arms and legs
  • Blood pressure upon standing
  • Reflexes
  • Response to temperature/vibration
 

More than half of patients (56%) treated with ONPATTRO showed improvement in nerve function from their starting point in the study, compared to placebo (4%).

Change in nerve function from baseline at 18 monthsa

Patients receiving ONPATTRO® (patisiran) showed improvement in nerve function at 18 months when compared to placebo

aNerve function was measured using a 304-point scale called the modified Neuropathy Impairment Score (mNIS) +7.

Patients receiving ONPATTRO showed improvement in quality of life compared to those who received placebo

Significant improvements in quality of life, compared to placebo, as measured byb:

  • Symptoms of neuropathy (numbness, tingling, pain, weakness, etc.)
  • Digestive health
  • Ability to perform everyday activities (dressing, bathing, walking, etc.)
  • Steadiness on feet

Change in quality of life from baseline at 18 monthsb

Patients receiving ONPATTRO® (patisiran) showed improvement in quality of life at 18 months when compared to placebo
bChange in quality of life was measured using a questionnaire (score range -4 to 136) called the Norfolk Quality of Life-Diabetic Neuropathy (QoL-DN) that evaluated the effect of the disease on patients’ daily life.

Patients treated with ONPATTRO also showed improvements in other measures

At 18 months, when compared to placebo, patients experienced:

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Decrease in symptoms
such as diarrhea, constipation, dizziness, difficulty urinating, and vomiting

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Better nutritional health
ONPATTRO-treated patients maintained a healthier weight

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Increase in walking speed
ONPATTRO-treated patients could walk faster

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Decrease in pain

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Decreased feelings of anxiety and depression