ONPATTRO Online Infusion Center Directory Registration

Fill out the form below to have your infusion center included in our online directory for patients and healthcare professionals.

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The ONPATTRO Infusion Center Directory will offer the user the opportunity to locate and contact an infusion site of care. The data collected in connection with the ONPATTRO Infusion Center Directory is for informational purposes only. No fees or other remuneration have been or will be exchanged for an infusion center’s inclusion in this database. Inclusion of centers in this database will be based on opt-in approval by authorized personnel for those sites listed. Alnylam Pharmaceuticals is not affiliated with, and inclusion in this database does not represent an endorsement of, recommendation for, or referral to, the infusion centers listed in this database. Likewise, participating infusion centers do not necessarily endorse the use of any Alnylam Pharmaceuticals products.

    • Important Safety Information

 

Infusion-Related Reactions

Infusion-related reactions (IRRs) have been observed in patients treated with ONPATTRO (patisiran). In a controlled clinical study, 19% of ONPATTRO-treated patients experienced IRRs, compared to 9% of placebo-treated patients. The most common symptoms of IRRs with ONPATTRO were flushing, back pain, nausea, abdominal pain, dyspnea, and headache.

To reduce the risk of IRRs, patients should receive premedication with a corticosteroid, acetaminophen, and antihistamines (H1 and H2 blockers) at least 60 minutes prior to ONPATTRO infusion. Monitor patients during the infusion for signs and symptoms of IRRs. If an IRR occurs, consider slowing or interrupting the infusion and instituting medical management as clinically indicated. If the infusion is interrupted, consider resuming at a slower infusion rate only if symptoms have resolved. In the case of a serious or life-threatening IRR, the infusion should be discontinued and not resumed.

  • Reduced Serum Vitamin A Levels and Recommended Supplementation

    ONPATTRO treatment leads to a decrease in serum vitamin A levels. Supplementation at the recommended daily allowance (RDA) of vitamin A is advised for patients taking ONPATTRO. Higher doses than the RDA should not be given to try to achieve normal serum vitamin A levels during treatment with ONPATTRO, as serum levels do not reflect the total vitamin A in the body.

    Patients should be referred to an ophthalmologist if they develop ocular symptoms suggestive of vitamin A deficiency (e.g. night blindness).

  • Adverse Reactions

    The most common adverse reactions that occurred in patients treated with ONPATTRO were upper respiratory tract infections (29%) and infusion‑related reactions (19%).

  • Indication

    ONPATTRO is indicated for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults.

  • For additional information about ONPATTRO, please see the full Prescribing Information.